![]() A ticket for battle-themed Timed Research awarding Stardust, Rare Candy XL, and one Star Piece will be available for US$1.During the Pokemon Go Lunar New Year Event, a special event timed research task will be available. Niantic has yet to release the last two Pokemon‘s shiny versions in the game. The Pokemon Go Festival of Lights event runs from November 5, 2021, to. The maximum number of sets you can play per day will be increased from five to 20 - for a total of 100 battles - from 12:00AM to 11:59PM local time each day The first ten Pokemon can hatch into their shiny alternatives. Pokemon GO Lunar New Year 2023 Event: Raids Prepare to battle the following.Rewards include the Geeta-Style Gloves avatar item Free battle-themed Timed Research will be available. ![]() Set to take place over the next week or so, the Lunar New. ![]()
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![]() ![]() Saref-Bank S, Ahmadi A, Paknahad Z, et al. Such steps, if implemented with other lifestyle changes, can facilitate the liberation of young males and females from obesity and disease.ġ. The implementation of curcumin, as part of a complete intervention program, shows promise due to its effectiveness over a short time periods as well as its simplicity (one capsule a day) and cost-effectiveness. Research continues to mount indicating multiple factors contributing to the epidemic, two of which includes an aberration in inflammatory markers and oxidative stress. In conclusion, there is an excess of 340 million obese/overweight children, worldwide. 1(2019) Furthermore, the study of Saref-Bank et al 1(2019) was novel because it concurrently evaluated reduction of inflammatory/oxidative markers using curcumin with a weight management program. 1(2017)4 Interestingly, the intervention group using curcumin, when compared to the control group, experienced a significant reduction in IL-6 and CRP levels as well as a reduction in oxidative stress markers measured by TAC and MDA. ![]() Key biomarkers of inflammation included C-reactive protein (a measure of the degree of inflammation, also known as CRP), interleukin-6 (an inflammatory cytokine), total anti-oxidant capacity (TAC), and malonaldehyde (a measure of overall lipid oxidation from free radical production, also known as MDA). 1(2017)īaseline blood samples, and samples at the end of the study, were collected and reviewed. 1(2017) One 500‐mg curcumin capsule per day or its placebo (randomly assigned) was considered for each participant for 10 weeks which was consumed with their main meals to enhance absorption. Throughout the duration of the study, a dietitian met all adolescents individually and prescribed a balanced diet according to Healthy Eating Plate advice. 1(2016) The study was conducted over 10 weeks and 30 participants were assigned to a control group and 30 participants to the intervention group. These participants had also been admitted to a pediatric cardiovascular research center clinic and were also participating in a weight management programs which helped encourage increasing physical activity, reducing refined foods, selecting healthier/whole foods, and improving overall lifestyle lifestyle. The study was structured as a randomized placebo-controlled clinical trial whereby 60 post-pubescent overweight/obese females aged 13-18 years were recruited for said experiment. I suggest really learning about how your supervisor is when it comes to flexibility and expectations because some departments are extremely strict while others are more flexible.Saref-Bank et al 1(2016) explored the efficaciousness of controlling LGCI via supplementation of curcumin. Pay could be WAY better (starting rate was only $15.75/hr with a bachelors) but it is also one of the only places in Asheville to get lab experience outside of hospitals, so there isn't much competition to offer higher pay. I worked with some really great people which made my time enjoyable, but during COVID most of the people that had been there for many years were furloughed and then never brought back on leaving most of the departments with new, less experienced employees. ![]() No raises or 401k match while I was there and this had been the situation for the years before I was hired as well. Almost everyone disapproves of the CEO and there is a lack of respect for the entire upper management team. The experience I had is not a reflection of the company as a whole. Department expectations and culture vary by your supervisor and mine was one of the best. I had a great experience at Genova, but that was greatly due to the department that I worked in. ![]() Click on the first instance of a "gene" label in this feature table. In the feature table, each labeled feature is hyperlinked to the sequence itself, which is at the bottom of the record. A gene may include multiple sections of coding sequences, so the same nucleotide sequence (shown in a number range) may be labeled as CDS and gene. CDS = a coding sequence, or region of nucleotides that corresponds with amino acids in a protein.Definitions of some of the feature labels can be found in the GenBank Sample Record. Scroll down the feature table of this mitochondrial DNA record. There are other types of mutations as well, but this short list should give you an idea of the possibilities.An interesting part of a Nucleotide record is the section labeled "FEATURES." Called the "feature table," this is the part that reflects scientists' annotations - notes on what biological features of interest are known about a sequence. This usually generates truncated proteins that are as useless as “hef atc ats at” is uninformative. In frameshifts, a similar error occurs at the DNA level, causing the codons to be parsed incorrectly. ![]() If we delete the first letter and parse the sentence in the same way, it doesn’t make sense. These changes are called frameshifts.įor example, consider the sentence, “The fat cat sat.” Each word represents a codon. Since protein-coding DNA is divided into codons three bases long, insertions and deletions can alter a gene so that its message is no longer correctly parsed. Insertions are mutations in which extra base pairs are inserted into a new place in the DNA.ĭeletions are mutations in which a section of DNA is lost, or deleted. So each sequence of three codes for an amino acid. This can have serious effects since the incomplete protein probably won’t function. ACGT is an acronym for the four types of bases found in a DNA molecule: adenine (A), cytosine (C), guanine (G), and thymine (T). 1 2 The standard genetic code is traditionally represented as an RNA codon table, because when proteins are made in a cell by ribosomes, it is messenger RNA (mRNA) that directs protein synthesis. A gene may include multiple sections of coding sequences, so the. CDS a coding sequence, or region of nucleotides that corresponds with amino acids in a protein. change an amino-acid-coding codon to a single “stop” codon and cause an incomplete protein. A codon table can be used to translate a genetic code into a sequence of amino acids. NCBI BLAST allows you to input a sequence from DNA, RNA or protein residues (amino acids) and find sequences that are identical or similar.Once the open reading frame is known the DNA sequence can be translated into its corresponding amino acid sequence. Typically only one reading frame is used in translating a gene (in eukaryotes), and this is often the longest open reading frame. change a codon to one that encodes the same amino acid and causes no change in the protein produced. The reading frame that is used determines which amino acids will be encoded by a gene. Most restriction enzymes and their corresponding methylases recognise simple unique nucleotide sequences in DNA.For example, sickle cell anemia is caused by a substitution in the beta-hemoglobin gene, which alters a single amino acid in the protein produced. change a codon to one that encodes a different amino acid and cause a small change in the protein produced.Here is a quick summary of a few of these: SubstitutionĪ substitution is a mutation that exchanges one base for another (i.e., a change in a single “chemical letter” such as switching an A to a G). There are many different ways that DNA can be changed, resulting in different types of mutation. Information on controversies in the public arena relating to evolution.Alignment with the Next Generation Science Standards.The big issues – Pacing, diversity, complexity, and trends.Macroevolution – Evolution above the species level.In eukaryotic cells, chromosomes always remain in the nucleus, but proteins are made at ribosomes in the cytoplasm or on the rough. 1: Transcription and translation (Protein synthesis) in a cell. Microevolution – Evolution within a population Instructions for making proteins with the correct sequence of amino acids are encoded in DNA.Mechanisms: the processes of evolution – Selection, mutation, migration, and more.The history of life: looking at the patterns – Change over time and shared ancestors.An introduction to evolution: what is evolution and how does it work?. You can access your email online by visiting Webmail and logging in with your account username and password. I will list the settings below you need to update your email client. We are not able to offer assistance on email clients unfortunately. My patience understandably is running thin. I am seriously outraged by this cavalier answer and I am going to post it on the Forum publicly. Just have the courtesy to read the history and do not give me a load of bull. I have endured lack of service from Plusnet for a week now and if soemthing is not sorted out, then I intend to make a formal complaint to Ofcom. Therefore please ensure that this is escalated to your manager immediately as a complaint. This ticket was opened by Alisdair Campbell, not by me. It is Plusnet that has created this chaos with your email system update which you then had to roll back. My settings have always been and still are exactly as given above in your childish answwer. I have been using Outlook on Plusnet for TWENTY years, probably before you were born. What on earth has that got to do with the problem ? I have been instructed by POLusnet Support to add the abover information to this ticket and you have the audacity to give me a lot of boloney about setting up my Outlkook email account. How dare you respond in this manner ? Please immediately escalate this to your manager. I have had the most outrageous answer to my ticket sent which I give further below, to which I have answered : I have just, as instructed by Plusnet staf f, uploaded the above information to the ticket raised by Plusnet staff - not by me. Subject: Mail delivery failed: returning message to senderĪre we making progress ? It would appear that all my mail is being tagged as "Spam" which would explain why it is not getting through. X-PN-Virus-Filtered: by PlusNet MXCore (v5.00) X-DMARC: Authentication-Results: dmarc=skipped X-KLMS-AntiPhishing: not scanned, license restriction X-KLMS-AntiSpam-Status: not scanned, license restriction X-CMAE-Envelope: MS4wfOi9Qoi/jMn117sejh3I+TOVrCgudd4JJpP58LVKdAFkIMhtIGJvpA1wVTR2hIr1YOp5Id4CYJFX080fq3aAXM8MTQkRpVUZKlSNGt6PKlAO Received: from (helo=)īy with esmtp (PlusNet MXCore v2.00) id 1h7OqT-0004d2-0b įinal-recipient: rfc822 smtp 550-Mailcore(2503): Your email was detected as spam. ** The remote server ? responded with: ** ?:? This message was created automatically by mail delivery software on the server. * A message that you sent to the following recipient could not be delivered due to a permanent error. This is an automatically generated Delivery Status Notification.ĭelivery to the following recipients failed permanently: This is an e-mail message sent automatically by Microsoft Outlook while testing the settings for your account. Mail delivery failed: returning message to sender I have just received the following email from an unknow sender (presumably Plusnet Support ) which reads : In case you ask, I have added it to the ticket but you never get any answer from the ticket. Using a third party email system is just not practical for obvious reasons. ![]() I have spent hours trying to unravel serious consequences entirely due to this. So please, please, please, please,please,please,please,please,please,please,please,please,please, can you sort this disaster out once and for all and tell us what you are doing actually doing about it rather than just bland answers. I have had one contact tell me also - note a different contact - that all my mails are going into his SPAM folder. Obviously I cannot give you the header of the email which was not received.īut clearly, this email exchange has nothing to do with 123-Reg or SPFs. I did not receive your email of 21 March 2019 so thank you for forwarding that to me. ![]() Re-sending email due to technical problems with my main email system. This is his reply, just received this evening, to my uk2.net address : Subject: RE: Caledonian Sky Tour of New Zealand - ref QB183181ĭear Mr. These are the details of the email I sent from Plusnet yesterday : I emailed a contact yesterday and because I had not received a reply, I emailed him again through another mail system (uk2.net). Yes definitely there is an on-going issue. Flexible Modes:Įxpert testers can utilise a full IDE to produce increased rough scripts, while new testers can use recordings and keywords to create automation tests. Katalon can handle every step of the process, including project organisation, test engendering, execution, report generation, and support. Testers can quickly build and perform automation test rough writings thanks to built-in example copies and explicit procedures on field-specific training. Using Katalon's which was before layouts and testing requirements, testers may execute their initial test suite quickly and easily. Quick & Easy Set-up:īeyond the first setup, Katalon Studio provides an easy way to configure the workspace. Given below are some of the key features of Katalon Studio Simple Deployment:Įverything a tester needs to deploy a robust test automation solution in a single, well-organized deployment package. This course will help you to achieve excellence in this domain. If you want to enrich your career and become a professional in Cypress, then enroll in " Cypress Online Training". It also offers a script option for people who are familiar with programming, which allows them to write Groovy test scripts. It offers a record & playback feature as well as a manual mode to assist non-programmers in creating automation test cases successfully. Katalon Studio is a free web, mobile, and web service test automation tool. Cross-Browser Testing Abilities and Compatible Web Browsers.Finding the Root Cause of Test Failures.This Katalon Vs Cypress blog will assist you in understanding and selecting which tool will be beneficial to the success of your organization. It helps teams to construct web test automation scripts. Cypress is a JavaScript test automation tool for web automation. Katalon is primarily meant for building and reusing automated UI test scripts without the need for coding. Katalon Studio is a robust automation tool with a Selenium-based engine that was initially released in January 2015. 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I can see this being annoying if you have to go up and down the stairs multiple times during your workout to access different machines - though, to be fair, you are at the gym to work out and move your body, so that’s not necessarily a bad thing! The Paramus location had cardio and resistance machines set up on both floors since there’s not enough space to include everything on one floor. There were no dedicated areas for strength training and cardio like I’ve seen at some other gyms. The space is long and narrow, so it’s easy to feel cramped. The gym is attached to another store, and Equinox didn’t have much room to expand when it was built. I think this is mostly due to the location itself. While I was working out, I sometimes felt like I was getting in the way of some of the trainers who were working with their clients at the time. There’s nothing wrong with that, but it’s not my style. The other members seemed to have expensive taste and were very trendy. I didn’t have any negative encounters with the members, but I felt a little out of place while I was there. Most members were at least in their 30s, which makes sense since college students or young professionals probably can’t afford a membership. Brand image also seems very important to Equinox as a whole, so I’m confident the staff would do their best to not have anyone tarnish their reputation. There are trainers walking around the gym floor all the time, so I’m sure they’d say something if they noticed anybody engaging in inappropriate behavior. I didn’t notice the staff having to police the members too much, but at gyms like Equinox, I’ve found that the members tend to be more mature and respectful. ![]() She wasn’t overly aggressive about getting me to sign up for a membership when I was at the club, but Equinox has been contacting me via email and text almost every day since I visited. When I checked in at the front desk, the woman who helped me was friendly and informative. It felt like a spa that added some gym equipment as an afterthought. The lobby has high-end marble and bamboo finishes and it definitely didn’t feel like a gym at first. ![]() I wasn’t sure I was in the right place when I first walked into Equinox.
![]() You can also check out our other shapes coloring pages on our website. Print these geometric coloring pages for free and have fun with it. For example, you can color the triangle in a bright color and the cityscape in a darker color. ![]() You can use different colors to create contrast and depth in the image. The triangle is made up of three lines and is the largest element in the image. This coloring sheet features a simple and elegant cityscape with a large triangle in the center. There are lots of white spaces ready to be filled with shapes, lines, or any forms the little artists may think of. To make them more enticing to color, these forms include strong, triangular, and rectangular details.Ĭolored pencils would be a natural fit for them.Ĭhildren can color inside the lines to enhance the vibrancy of these eye-catching forms or let their creativity run free and even add more shapes of their own. This geometric coloring page is simple but effective. If you were to cut a mandala in half, both sides should look identical.Ĭoloring these symmetrical and highly detailed drawings is a lot of fun, but it is also worth noting that mandalas are used in Hinduism and Buddhism as a technique for meditation and teaching awareness. In reality, a mandala is an image with a circular center (the term mandala means “circle” in Sanskrit). Do you know what mandalas are?įor many of us, mandalas are just cool, repeated designs that may also be used as a simple DIY project. The first geometric coloring page on our list features 7 circles with geometric details that make them look almost like mandalas. Print them out for free and let the fun begin! 15 Brand New Geometric Coloring Pages – Free to Print and Color Geometric coloring sheets are also a fun coloring exercise for toddlers and preschoolers who are getting ready for kindergarten, as well as kindergarteners themselves. These geometric coloring pages of shapes are a fantastic method to accomplish just that. Sure, maybe you don’t know the difference between a hexagon and a trapezoid at first look, but that’s why you should keep practicing from time to time. You can find all these landscapes among our beautiful drawings to colour of landscapes at Christmas.Remember when you were learning geometric shapes as a kid? Those abilities have come in helpful throughout life. The House of Santa Claus at the North Pole and the sleigh of Santa flying over houses on Christmas Eve are fantastic landscapes fully related to Christmas around the world. The famous Christmas markets illuminated with garlands of lights with stalls full of typical products for the Christmas celebrations and many visitors are the places with more atmosphere in many towns and cities. The houses with Christmas tree adorned in their garden at the streets of towns and cities. The steeples of churches stand out in the towns distant views. The villages in the middle of a landscape of peace and harmony. The firs and the pretty houses with rooftops full of snow. ![]() Starry nights, i.e., the skies with a lot of stars. The assimilation between Christmas and the winter is due in large part to the preeminence of the literature and movies made in certain countries from the northern hemisphere. When the reality is that Christmas is celebrated on the same date throughout the world and in many parts of the planet coincides with the summer period. Christmas landscapesThose landscapes that we often recognize as Christmas's landscapes usually tend to be in winter and at night. ![]() ![]() If you believe a post or comment was wrongfully removed or is not showing up, please include a link when contacting us. If you have any doubts before posting to r/euphoria, please feel free to message the mods. Not following these rules may result in a ban, which can be permanent depending on severity. Do not make a post or comment asking others for access to other people’s streaming service accounts.But the discussion of piracy, such as torrenting or illicit streaming, as well as the sharing of such material, is strictly forbidden. How you source your media is your business.Posts to r/euphoria must include appropriate flair.Posts that are simply a picture of one of the show's actors outside of the context of Euphoria, etc. Posts to r/euphoria must be of quality and inspire discussion.Not all leaks are lawful and might be removed by reddit.īetween two seasons, photos from set and details shared by insiders, etc. The title must include the word leak and appropriate flair, but cannot disclose the content, in line with our spoiler policy. Leaks are allowed in separate threads only. They might stem from insiders working on set or people who have had the chance to preview episodes ahead of their public release. Leaks refer to information that is not accessible to the public under normal circumstances. While every leak is a spoiler, not every spoiler is a leak. Spoilers in titles are strictly prohibited. Comments in threads that are not directly related to a current episode must use appropriate formatting. In-Season Policy: While a season is airing and before the official announcement of a new season, all plot details of the current season are considered a spoiler. This rule currently applies to Season 1 and the Special Episodes. Post-Season Policy: Once a new season has been officially announced and the first episode of that season has aired, spoilers for the previous season are allowed, including in titles. We have two rulesets on spoilers, depending on where the show is currently at. Spoilers are descriptions of an important plot development, which if previously known may reduce surprise or suspense for a first-time viewer. This includes playlists, merchandise, artwork, etc.Īny form of promotion or advertisement must be approved by moderators in advance. Please do not sell or promote your stuff here. ![]() These posts can be episode discussions, theories, casting announcements, series announcements, criticisms of the series, questions, reactions, etc. Only posts pertaining to HBO’s Euphoria are allowed here. Shittiness is a great word that includes, but is not limited to, personal attacks or insults, rudeness, racism, misogyny, homophobia, transphobia, xenophobia, transmedicalism, and all other forms of bigotry or incivility. The golden rule of r/euphoria is no shittiness to other people. Above all, we ask members of r/euphoria to follow reddit’s content policy.Rules Click here for the full list of rules.Īll rules are subject to our moderator’s individual discretion! 1. To view the spoiler, click or tap the spoiler text. If you have something spoilery to say that is outside of the established scope of the thread, use Reddit's built-in spoiler function. ' The pilot of Euphoria aired on HBO in June 2019. To return to Old Reddit once you're on the discussion page, replace "www" in the address bar with "old". naked in front of each other, so you build this bond and this trust and this support system. Episode Discussion ArchiveĮpisode Discussions have moved! Go to New Reddit and navigate to different discussions using the menu bar below the subreddit banner. We're exhausted writing all of that, so it isn't surprising that Zendaya described filming this season as "f-king brutal" to The Cut.HBO's Euphoria: A group of high school students try to discover their own identities while dealing with drugs, trauma, love, and social media. Cassie ( Sydney Sweeney) suffered a full on breakdown after sleeping with her best friend's ex, Maddy ( Alexa Demie) experienced a trauma worse than her season one strangulation and Ethan ( Austin Abrams) broke out of his comfort zone with a homoerotic dance number in the school play. Still, Rue wasn't the only character to have an emotionally charged second season. Thankfully, not all hope was lost, as the season two finale showed Rue preparing to make amends for her drug-fueled wrongdoings. Over the last seven weeks, we watched Rue ( Zendaya) struggle with addiction, almost get human trafficked, kick down a door and alienate every loved one in her life. It's not that we didn't enjoy the sophomore season of the Sam Levinson-created teen drama, but we just found the latest installment wildly stressful. Euphoria's second season has come to end and, in the words of Cassie, we've never ever been happier. ![]() Her interests lie in materials for energy applications and deep earth geochemistry. ![]() Prior to this she completed a PhD in Earth Sciences at the University of Cambridge, UK in igneous petrology and mantle geochemistry. ![]() ORCID 0000-0003-2616-3193 Deputy Editor: Eve RooksĮve joined Scientific Reports in 2019, after working as an editor on the Royal Society of Chemistry’s materials chemistry and engineering portfolio for 3 years. She joined Scientific Reports in January 2019. ORCID 0000-0002-8820-8468 Deputy Editor: Elizabeth MannĮlizabeth has a background in pharmacology and completed her PhD in neuropharmacology at King's College London, UK. She completed her PhD in nanomedicine from Middlesex University and has experience in nanoparticles design and applications. ORCID 0000-0003-0316-1363 Deputy Editor: Anam AkhtarĪnam joined Scientific Reports in October 2023 after working for four years at Communications Biology. He was an editor at Genome Biology for four years before joining Scientific Reports in August 2016. He did his PhD and postdoctoral research in single-cell proteomics at Imperial College London, UK. Rafal's background is analytical and biological chemistry. In-house Editors Chief Editor: Rafal Marszalek In-house Editors led by Chief Editor Dr Rafal Marszalek.From our Editorial Board Members and Senior Editorial Board to our in-house Editors, we work together to ensure that your research is expertly handled and that we consider it to be technically sound, scientifically valid, and ultimately suitable for publication. Scientific Reports is run by a team of experienced editors who are experts in their fields. ![]() Transchondral fractures (osteochondritis dissecans) of the talus. doi: 10.2106/00004623-198062010-00014.īerndt A.L., Harty M. Osteochondral lesion of the talus, (cartilage damage of the ankle) can occur from a traumatic fracture or ankle sprain when the bones in the ankle joint hit. This most common symptom of osteochondritis dissecans might be triggered by physical activity walking up stairs, climbing a hill or playing sports. doi: 10.1302/0301-620X.82B3.10064.Ĭanale S.T., Belding R.H. Depending on the joint thats affected, signs and symptoms of osteochondritis dissecans might include: Pain. Arthroscopic findings in acute fractures of the ankle. Hintermann B., Regazzoni P., Lampert C., Stutz G., Gächter A. Lateral radiograph of the leg demonstrates osteochondritis dissecans in the. 52, 53, 54 Anteroposterior radiograph of the leg reveals osteochondritis dissecans in the medial talar dome (arrowhead). Coronal fat-suppressed proton-density-weighted magnetic resonance image demonstrates an osteochondral fragment in situ (arrow) at the medial talar dome. The usual sites of OCD of the talar dome are the posteromedial aspect (56) and the anterolateral aspect (44. Osteochondritis dissecans of the talus (transchondral fractures of the talus): Review of the literature and new surgical approach for medial dome lesions. Osteochondritis dissecans (OCD) of the medial talar dome in a 43-year-old woman. Osteochondral lesions of talus associated with ankle fractures. This article summarizes the contemporary concepts in the clinical evaluation and treatment of OLTs with particular emphasis on surgical strategies.Īrthroscopy Cartilage injury OCD OLT Osteochondral Talus.īoraiah S., Paul O., Parker R.J., Miller A.N., Hentel K.D., Lorich D.G. In patients with a large lesion or after a failure of previous bone marrow stimulation, biologic restoration techniques including the use of particulate juvenile cartilage techniques, autogenous chondrocyte implantation, and osteochondral autograft or allograft transplantation may have role. Arthroscopic treatment of the OLTs aims to restore ankle joint function and pain relief by the removal of the chondral or osteochondral fragment, debridement and stabilization of cartilage rim and subchondral bone, and stimulate healing of the bone and damaged cartilage. While the natural history of the OLTs is not well understood, surgical treatment is often required especially in chronic cases and acute cases with displaced articular fragments. Fractures of the talar dome may be medial or lateral, and they are usually the result of inversion injuries, although medial injuries may be atraumatic. The fracture defect was on the medial talar dome in six patients, and on the lateral talar. Symptoms related to this condition are nonspecific including pain, swelling, stiffness, and mechanical symptoms of locking and catching. Of the sixteen OCFT, seven were grade III, and nine were grade IV. Adjacent subtle marrow edema seen in the medial aspect of talus bone. Osteochondral lesion of the talus (OLT) is a common condition associated with ankle injury that brings challenges in the diagnosis and treatment. Small well defined hypointense signal lesion is seen on the T1W images in the medial talar dome at subchondral region. |
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